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Page 1
Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency.
Cong K, Peng M, Kousholt AN, Lee WTC, Lee S, Nayak S, Krais J, VanderVere-Carozza PS, Pawelczak KS, Calvo J, Panzarino NJ, Turchi JJ, Johnson N, Jonkers J, Rothenberg E, Cantor SB. Cong K, et al. Among authors: lee wtc. Mol Cell. 2021 Aug 5;81(15):3128-3144.e7. doi: 10.1016/j.molcel.2021.06.011. Epub 2021 Jul 2. Mol Cell. 2021. PMID: 34216544 Free PMC article.
BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment.
D'Alessandro G, Whelan DR, Howard SM, Vitelli V, Renaudin X, Adamowicz M, Iannelli F, Jones-Weinert CW, Lee M, Matti V, Lee WTC, Morten MJ, Venkitaraman AR, Cejka P, Rothenberg E, d'Adda di Fagagna F. D'Alessandro G, et al. Among authors: lee wtc. Nat Commun. 2018 Dec 18;9(1):5376. doi: 10.1038/s41467-018-07799-2. Nat Commun. 2018. PMID: 30560944 Free PMC article.